- Title
- Association between Blood Donor Demographics and Post-injury Multiple Organ Failure after Polytrauma
- Creator
- Amico, Francesco; Efird, Jimmy T.; Briggs, Gabrielle D.; Lott, Natalie J.; King, Kate L.; Hirani, Rena; Balogh, Zsolt J.
- Relation
- Annals of Surgery Vol. 277, Issue 1, p. E170-E174
- Publisher Link
- http://dx.doi.org/10.1097/SLA.0000000000004754
- Publisher
- Lippincott Williams & Wilkins
- Resource Type
- journal article
- Date
- 2023
- Description
- Objective: To test the hypothesis that blood donor demographics are associated with transfused polytrauma patients' post-injury multiple organ failure (MOF) status. Summary of Background Data: Traumatic shock and MOF are preventable causes of death and post-traumatic hemorrhage is a frequent indication for transfusion. The role of blood donor demographics on transfusion recipients is not well known. Methods: A log-linear analysis accounting for the correlated structure of the data based on our prospective MOF database was utilized. Tests for trend and interaction were computed using a likelihood ratio procedure. Results: A total of 229 critically injured transfused trauma patients were included, with 68% of them being males and a mean age of 45 years. On average 10 units of blood components were transfused per patient. A total of 4379 units of blood components were donated by donors aged 46 years on average, 74% of whom were males. Blood components used were red blood cells (47%), cryoprecipitate (29%), fresh frozen plasma (24%), and platelets (less than 1%). Donor-recipient sex mismatched red blood cells transfusions were more likely to be associated with MOF (P = 0.0012); fresh frozen plasma and cryoprecipitate recipients were more likely to experience MOF when transfused with a male (vs female) component (P = 0.0014 and <0.0001, respectively). Donor age was not significantly associated with MOF for all blood components. Conclusions: Blood components donor sex, but not age, may be an important factor associated with post-injury MOF. Further validation of our findings will help guide future risk mitigation strategies specific to blood donor demographics.
- Subject
- blood components; blood donor demographics; polytrauma; post-injury multiple organ failure; transfusion
- Identifier
- http://hdl.handle.net/1959.13/1478842
- Identifier
- uon:50236
- Identifier
- ISSN:0003-4932
- Language
- eng
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